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Article

SMARCA4 mutations in KRAS-mutant lung adenocarcinoma: a multi-cohort analysis.

Molecular oncology - 1 Feb 2021

Liu Liang, Ahmed Tamjeed, Petty William J, Grant Stefan, Ruiz Jimmy, Lycan Thomas W, Topaloglu Umit, Chou Ping-Chieh, Miller Lance D, Hawkins Gregory A, Alexander-Miller Martha A, O'Neill Stacey S, Powell Bayard L, D'Agostino Ralph B, Munden Reginald F, Pasche Boris, Zhang Wei

Abstract excerpt

KRAS is a key oncogenic driver in lung adenocarcinoma (LUAD). Chromatin-remodeling gene SMARCA4 is comutated with KRAS in LUAD; however, the impact of SMARCA4 mutations on clinical outcome has not been adequately established. This study sought to shed light on the clinical significance of SMARCA4 mutations in LUAD. The association of SMARCA4 mutations with survival outcomes was interrogated in four independent...

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Identifiers

PMID: 33107184
DOI: 10.1002/1878-0261.12831
PMCID: PMC7858279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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