Article

Murine lupus is Neutrophil Elastase-independent in the MRL.Fas <i> <sup>lpr</sup> </i> model

2019-11-27

Abstract excerpt

Loss of tolerance to nuclear antigens and multisystem tissue destruction is a hallmark of systemic lupus erythematosus (SLE). Although the source of autoantigen in lupus remains elusive, a compelling hypothetical source is dead cell debris that drives autoimmune activation. Prior reports suggest that neutrophil extracellular traps (NETs) and their associated death pathway, NETosis, are sources of autoantigen in SL...

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Literature Corpus work: 4cc61942-29f0-560c-96c2-a15cf804f1c4
DOI: 10.1101/857243

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