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Article

Lupus in the Fas lane?

Journal of the Royal College of Physicians of London - 1 Jan 2000

Singh A K

Abstract excerpt

Fas is a 43 kDa glycoprotein molecule which is involved in inducing apoptosis in both B and T lymphocytes. In the murine MRL/Ipr-Ipr model of systemic lupus erythematosus (SLE), the lymphoproliferation (lpr) mutation results in defective transcription of the gene that codes for the Fas protein. MRL mice which carry the homozygous recessive Ipr mutation develop a severe early-onset genetically predetermined...

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Identifiers

PMID: 8748102
PMCID: PMC5401240

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Source receipt: pubmed, retrieved 7 Sept 2026.

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