Lupus in the Fas lane?

Article

Lupus in the Fas lane?

Journal of the Royal College of Physicians of London - 1 Jan 2000

Singh A K

Abstract excerpt

Fas is a 43 kDa glycoprotein molecule which is involved in inducing apoptosis in both B and T lymphocytes. In the murine MRL/Ipr-Ipr model of systemic lupus erythematosus (SLE), the lymphoproliferation (lpr) mutation results in defective transcription of the gene that codes for the Fas protein. M...

Topics

Animals
Apoptosis
Autoimmune Diseases
B-Lymphocytes
Disease Models, Animal
Down-Regulation
Humans
Lupus Erythematosus, Systemic
Mice
Mutation
fas Receptor

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