Article
Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus.
The Journal of clinical investigation - 1 Jul 2013
Knight Jason S, Zhao Wenpu, Luo Wei, Subramanian Venkataraman, O'Dell Alexander A, Yalavarthi Srilakshmi, Hodgin Jeffrey B, Eitzman Daniel T, Thompson Paul R, Kaplan Mariana J
Abstract excerpt
Recent evidence suggests that enhanced neutrophil extracellular trap (NET) formation activates plasmacytoid dendritic cells and serves as a source of autoantigens in SLE. We propose that aberrant NET formation is also linked to organ damage and to the premature vascular disease characteristic of human SLE. Here, we demonstrate enhanced NET formation in the New Zealand mixed 2328 (NZM) model of murine lupus. NZM...
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