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Article

A Fast and Accurate Method for Genome-Wide Time-to-Event Data Analysis and Its Application to UK Biobank.

American journal of human genetics - 6 Aug 2020

Bi Wenjian, Fritsche Lars G, Mukherjee Bhramar, Kim Sehee, Lee Seunggeun

Abstract excerpt

With increasing biobanking efforts connecting electronic health records and national registries to germline genetics, the time-to-event data analysis has attracted increasing attention in the genetics studies of human diseases. In time-to-event data analysis, the Cox proportional hazards (PH) regression model is one of the most used approaches. However, existing methods and tools are not scalable when analyzing a...

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PMID: 32589924
DOI: 10.1016/j.ajhg.2020.06.003
PMCID: PMC7413891

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