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Article

Monoallelic IDH1 R132H Mutation Mediates Glioma Cell Response to Anticancer Therapies via Induction of Senescence.

Molecular cancer research : MCR - 1 Nov 2021

Zhan Daqian, Ma Ding, Wei Shuang, Lal Bachchu, Fu Yi, Eberhart Charles, Laterra John, Ying Mingyao, Li Yunqing, Meeker Alan, Lopez-Bertoni Hernando, Xia Shuli

Abstract excerpt

Heterozygous isocitrate dehydrogenase (IDH) R132H mutation (IDH1R132H/WT) is an early event during gliomagenesis. Clinically, patients with glioma carrying mutant IDH1 respond better to antitumor therapies. However, the mechanism by which IDH1 mutations contribute to gliomagenesis and therapeutic response remains elusive. Here we report that senescence is involved in the improved therapeutic responses of mutant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34348994
DOI: 10.1158/1541-7786.MCR-21-0284
PMCID: PMC8568642

Genes

IDH1
ATRX
ATR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Monoallelic IDH1 R132H Mutation Mediates Glioma Cell Response to Anticancer Therapies via Induction of Senescence.PMID 34348994Read ↗

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IDH1-R132H acts as a tumor suppressor in glioma via epigenetic up-regulation of the DNA damage responseSemantic proximity Read ↗

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D-2HG Inhibits Glutamine Synthetase Activity and Induces Senescence in IDH-Mutant Gliomas.Semantic proximity Read ↗

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Sirtuin 2 inhibition modulates chromatin landscapes genome-wide to induce senescence in ATRX-deficient malignant gliomaSemantic proximity Read ↗

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