Article
Inhibition of SETMAR-H3K36me2-NHEJ repair axis in residual disease cells prevents glioblastoma recurrence.
Neuro-oncology - 18 Dec 2020
Kaur Ekjot, Nair Jyothi, Ghorai Atanu, Mishra Saket V, Achareker Anagha, Ketkar Madhura, Sarkar Debashmita, Salunkhe Sameer, Rajendra Jacinth, Gardi Nilesh, Desai Sanket, Iyer Prajish, Thorat Rahul, Dutt Amit, Moiyadi Aliasgar, Dutt Shilpee
Abstract excerpt
BACKGROUND: Residual disease of glioblastoma (GBM) causes recurrence. However, targeting residual cells has failed, due to their inaccessibility and our lack of understanding of their survival mechanisms to radiation therapy. Here we deciphered a residual cell-specific survival mechanism essential for GBM relapse. METHODS: Therapy resistant residual (RR) cells were captured from primary patient samples and cell...
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