Article
Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma.
Cell - 28 Jan 2016
Ceccarelli Michele, Barthel Floris P, Malta Tathiane M, Sabedot Thais S, Salama Sofie R, Murray Bradley A, Morozova Olena, Newton Yulia, Radenbaugh Amie, Pagnotta Stefano M, Anjum Samreen, Wang Jiguang, Manyam Ganiraju, Zoppoli Pietro, Ling Shiyun, Rao Arjun A, Grifford Mia, Cherniack Andrew D, Zhang Hailei, Poisson Laila, Carlotti Carlos Gilberto, Tirapelli Daniela Pretti da Cunha, Rao Arvind, Mikkelsen Tom, Lau Ching C, Yung W K Alfred, Rabadan Raul, Huse Jason, Brat Daniel J, Lehman Norman L, Barnholtz-Sloan Jill S, Zheng Siyuan, Hess Kenneth, Rao Ganesh, Meyerson Matthew, Beroukhim Rameen, Cooper Lee, Akbani Rehan, Wrensch Margaret, Haussler David, Aldape Kenneth D, Laird Peter W, Gutmann David H, Noushmehr Houtan, Iavarone Antonio, Verhaak Roel G W
Abstract excerpt
Therapy development for adult diffuse glioma is hindered by incomplete knowledge of somatic glioma driving alterations and suboptimal disease classification. We defined the complete set of genes associated with 1,122 diffuse grade II-III-IV gliomas from The Cancer Genome Atlas and used molecular profiles to improve disease classification, identify molecular correlations, and provide insights into the progression...
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