Article

Association of RDoC dimensions with post-mortem brain transcriptional profiles in Alzheimer’s Disease

2024-10-08

Abstract excerpt

<h4>INTRODUCTION</h4> Neuropsychiatric symptoms are common in people with Alzheimer’s disease (AD) across all severity stages. Their heterogeneous presentation and variable temporal association with cognitive decline suggest shared and distinct biological mechanisms. We hypothesized that specific patterns of gene expression associate with distinct NIMH Research Domain Criteria (RDoC) domains in AD. <h4>METHODS</h4...

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Literature Corpus work: 0f1976e9-4653-5b39-bc09-8d04584112b3
DOI: 10.1101/2024.10.07.24315057

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