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Article

The evolution of gene expression and binding specificity of the largest transcription factor family in primates.

Evolution; international journal of organic evolution - 1 Jan 2016

Kapopoulou Adamandia, Mathew Lisha, Wong Alex, Trono Didier, Jensen Jeffrey D

Abstract excerpt

The KRAB-containing zinc finger (KRAB-ZF) proteins represent the largest family of transcription factors (TFs) in humans, yet for the great majority, their function and specific genomic target remain unknown. However, it has been shown that a large fraction of these genes arose from segmental duplications, and that they have expanded in gene and zinc finger number throughout vertebrate evolution. To determine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26593440
DOI: 10.1111/evo.12819
PMCID: PMC4894471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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