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Article

Mapping disease loci to biological processes via joint pleiotropic and epigenomic partitioning.

Cell genomics - 8 Apr 2026

Kerner Gaspard, Kamitaki Nolan, Strober Benjamin, Price Alkes L

Abstract excerpt

Genome-wide association studies have identified thousands of disease-associated loci, yet their biological interpretation remains limited. We propose joint pleiotropic and epigenomic partitioning (J-PEP), a clustering framework that integrates pleiotropic SNP effects on auxiliary traits and tissue-specific epigenomic data to partition disease-associated loci into biologically distinct clusters. We introduce a...

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Share to Chromosome Mapping
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 41592567
DOI: 10.1016/j.xgen.2025.101138
PMCID: PMC13069866

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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