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<i>HLA-A</i>*<i>02:01</i>allele is associated with decreased risk and a longer survival in pancreatic cancer: Results from an exhaustive analysis of the<i>HLA</i>variation in PDAC

2024-08-29

Abstract excerpt

<h4>ABSTRACT</h4> Genetic susceptibility loci are associated with PDAC risk and survival, but the impact of germline HLA region variation remains largely unexplored. This study examined HLA I-II alleles within the PanGenEU study and validated our findings using external datasets (UK Biobank, TCGA, PAN-NGS trial, and Caris trial). HLA-A*02:01and HLA-B*49 alleles were linked to a decreased risk of PDAC, whereas HLA-...

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Literature Corpus work
4c1cbe03-6277-5332-b9b9-8954adcf7fe4
DOI
10.1101/2024.08.29.24312704
Open publication

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<i>HLA-A</i>*<i>02:01</i>allele is associated with decreased risk and a longer survival in pancreatic cancer: Results from an exhaustive analysis of the<i>HLA</i>variation in PDACDOI 10.1101/2024.08.29.24312704
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