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Article

HLA diversity unveils susceptibility and organ-specific occurrence of second primary cancers: a prospective cohort study.

BMC medicine - 8 Oct 2024

Rong Zi-Xuan, Wei Wei, Zeng Qin, Cai Xiao-Ting, Wang Yuan-Yuan, Wang Jian, Luo He-San, Xiao Lu-Shan, Lin Jia-Run, Bai Xue, Zhang Yan-Pei, Han Duan-Duan, Dong Zhong-Yi, Wang Wei, Wu De-Hua, Ma Si-Cong

Abstract excerpt

BACKGROUND: Up to 17% of cancer survivors have been reported to develop second primary cancers (SPC), which cause significant physical and economic distress and often complicate clinical decision-making. However, understanding of SPC remains limited and superficial. Human leukocyte antigen (HLA) is characterized by its polymorphism and has been associated with various diseases. This study aims to explore the role...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39380026
DOI: 10.1186/s12916-024-03676-6
PMCID: PMC11462672

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