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Article

Deciphering the role of complement system genes in pancreatic cancer susceptibility and prognosis.

Nature communications - 28 Nov 2025

Langtry Alberto, Rabadan Raul, Alonso Lola, Filip Ioan, Sabroso-Lasa Sergio, Moreno-Oya Ane, Lawlor Rita, Carrato Alfredo, Alvarez-Gallego Rafael, Iglesias Mar, Molero Xavier, Löhr Matthias J, Michalski Christoph W, Perea José, O'Rorke Michael, Barberà Victor M, Tardón Adonina, Farré Antoni, Muñoz-Bellvís Luís, Crnogorac-Jurcevic Tatjana, Domínguez-Muñoz Enrique, Gress Thomas M, Greenhalf William, Sharp Linda, Balsells Joaquim, Costello Eithne, Kleeff Jörg, Kong Bo, Mora Josefina, O'Driscoll Damian, Scarpa Aldo, Ye Weimin, Real Francisco X, López de Maturana Evangelina, Malats Núria

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) genetic susceptibility is partially identified. The complement system (CS) influences carcinogenesis and participates in immunological defense and homeostasis; however, its role in PDAC genetic susceptibility and prognosis is underexplored. The association of SNPs within 111 CS-related genes with PDAC risk is assessed in the PanGenEU study and validated in the UKBiobank. We...

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Source

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Identifiers

PMID: 41315260
DOI: 10.1038/s41467-025-65811-y
PMCID: PMC12663176

Genes

CS
A2M
C4A
CFI
F2R
F2RL2
F3
FCN1
FGA
FGG
PLAT
SERPINE1

Variants

Provenance

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