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Article

Risk of pancreatic ductal adenocarcinoma associated with carriage of BRCA1 and/or BRCA2 mutation: A systematic review and meta-analysis.

Journal of surgical oncology - 1 Nov 2022

McGarry Jennifer L, Creavin Ben, Kelly Michael E, Gallagher Tom K

Abstract excerpt

Germline BRCA1/2 mutations lead to malfunction of DNA damage repair pathways and predispose to pancreatic ductal adenocarcinoma (PDAC). The aim of this study is to synthesise the available research on this topic. Four studies reporting risk ratio (RR) were included in the final meta-analysis to minimise misrepresenting our results by combining separate risk estimates. Our meta-analysis revealed a statistically...

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Identifiers

PMID: 35770919
DOI: 10.1002/jso.26994

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