Article
Polymorphisms within autophagy-related genes as susceptibility biomarkers for pancreatic cancer: A meta-analysis of three large European cohorts and functional characterization.
International journal of cancer - 15 Jan 2025
Gálvez-Montosa Fernando, Peduzzi Giulia, Sanchez-Maldonado José Manuel, Ter Horst Rob, Cabrera-Serrano Antonio J, Gentiluomo Manuel, Macauda Angelica, Luque Natalia, Ünal Pelin, García-Verdejo Francisco José, Li Yang, López López José Antonio, Stein Angelika, Bueno-de-Mesquita H Bas, Arcidiacono Paolo Giorgio, Zanette Dalila Luciola, Kahlert Christoph, Perri Francesco, Soucek Pavel, Talar-Wojnarowska Renata, Theodoropoulos George E, Izbicki Jakob R, Tamás Hussein, Van Laarhoven Hanneke, Nappo Gennaro, Petrone Maria Chiara, Lovecek Martin, Vermeulen Roel C H, Adamonis Kestutis, Reyes-Zurita Fernando Jesus, Holleczek Bernd, Sumskiene Jolanta, Mohelníková-Duchoňová Beatrice, Lawlor Rita T, Pezzilli Raffaele, Aoki Mateus Nobrega, Pasquali Claudio, Petrenkiene Vitalija, Basso Daniela, Bunduc Stefania, Comandatore Annalisa, Brenner Hermann, Ermini Stefano, Vanella Giuseppe, Goetz Mara R, Archibugi Livia, Lucchesi Maurizio, Uzunoglu Faik Guntac, Busch Olivier, Milanetto Anna Caterina, Puzzono Marta, Kupcinskas Juozas, Morelli Luca, Sperti Cosimo, Carrara Silvia, Capurso Gabriele, van Eijck Casper H J, Oliverius Martin, Roth Susanne, Tavano Francesca, Kaaks Rudolf, Szentesi Andrea, Vodickova Ludmila, Luchini Claudio, Schöttker Ben, Landi Stefano, Dohan Orsolya, Tacelli Matteo, Greenhalf William, Gazouli Maria, Neoptolemos John P, Cavestro Giulia Martina, Boggi Ugo, Latiano Anna, Hegyi Péter, Ginocchi Laura, Netea Mihai G, Sánchez-Rovira Pedro, Canzian Federico, Campa Daniele, Sainz Juan
Abstract excerpt
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with patients having unresectable or metastatic disease at diagnosis, with poor prognosis and very short survival. Given that genetic variation within autophagy-related genes influences autophagic flux and susceptibility to solid cancers, we decided to investigate whether 55,583 single nucleotide polymorphisms (SNPs) within 234...
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