Article

Assessment of computational methods for the analysis of single-cell ATAC-seq data

2019-08-18

Abstract excerpt

<h4>Background</h4> Recent innovations in single-cell Assay for Transposase Accessible Chromatin using sequencing (scATAC-seq) enable profiling of the epigenetic landscape of thousands of individual cells. scATAC-seq data analysis presents unique methodological challenges. scATAC-seq experiments sample DNA, which, due to low copy numbers (diploid in humans) lead to inherent data sparsity (1-10% of peaks detected...

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Literature Corpus work: 234559f2-bf83-5ee3-8c9e-49e4993434ad
DOI: 10.1101/739011

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