TRIM36 Catalyzes K63-Linked Ubiquitination of TAK1 to Drive Septic Inflammation

Abstract excerpt

<title>Abstract</title> <p>The Toll-like receptor 4 (TLR4) pathway is critical for initiating innate immunity; however, its dysregulation drives pathological inflammation in diseases such as sepsis. Here, we identify tripartite motif protein 36 (TRIM36) as a key positive regulator that amplifies TLR4 signaling. TRIM36 expression was robustly upregulated in macrophages upon lipopolysaccharide (LPS) challenge. Mech...

Topics

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• Autophagy
• Autophagy in Disease and Therapy
• Inflammasome and immune disorders
• Inflammasomes
• interferon and immune responses
• Kawasaki Disease and Coronary Complications
• RNA regulation and disease
• Viral Infections and Vectors

Identifiers and source

Literature Corpus work

4bfb3589-4b1b-5aea-b5c3-07225de6a95e

DOI

10.21203/rs.3.rs-9884192/v1