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Article

TRIM-directed selective autophagy regulates immune activation.

Autophagy - 4 May 2017

Kimura Tomonori, Jain Ashish, Choi Seong Won, Mandell Michael A, Johansen Terje, Deretic Vojo

Abstract excerpt

Selectivity of autophagy is achieved by target recognition; however, the number of autophagy receptors identified so far is limited. In this study we demonstrate that a subset of tripartite motif (TRIM) proteins mediate selective autophagy of key regulators of inflammatory signaling. MEFV/TRIM20, and TRIM21 act as autophagic receptors recognizing their cognate targets and delivering them for autophagic...

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Source

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Identifiers

PMID: 26983397
DOI: 10.1080/15548627.2016.1154254
PMCID: PMC5446080

Genes

MEFV
TRIM21
CASP1
BECN1
GABARAP
NLRP1
NLRP3
ULK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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