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Article

Viral infection and spread are inhibited by the polyubiquitination and downregulation of TRPV2 channel by the interferon-stimulated gene TRIM21

1 Apr 2024

Abstract excerpt

Interferon (IFN) contributes to the host's antiviral response by inducing IFN-stimulated genes (ISGs). However, their functional targets and the mechanism of action remain elusive. Here, we report that one such ISG, TRIM21, interacts with and degrades the TRPV2 channel in myeloid cells, reducing its expression and providing host protection against viral infections. Moreover, viral infection upregulates TRIM21 in...

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PMID: 38613787
DOI: 10.1016/j.celrep.2024.114095

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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