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Article

The Function of TRIM25 in Antiviral Defense and Viral Immune Evasion

20 May 2025

Abstract excerpt

Tripartite motif (TRIM) 25 is a member of the TRIM E3 ubiquitin ligase family, which plays multiple roles in anti-tumor and antiviral defenses through various pathways. Its RBCC and SPRY/PRY domains work cooperatively for its oligomerization and subsequent activation of ligase activity. TRIM25 expression is regulated by several proteins and RNAs, and it functionally participates in the post-transcriptional and...

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PMID: 40431746
DOI: 10.3390/v17050735

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