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Article

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.

The Journal of cell biology - 14 Sept 2015

Kimura Tomonori, Jain Ashish, Choi Seong Won, Mandell Michael A, Schroder Kate, Johansen Terje, Deretic Vojo

Abstract excerpt

The present paradigms of selective autophagy in mammalian cells cannot fully explain the specificity and selectivity of autophagic degradation. In this paper, we report that a subset of tripartite motif (TRIM) proteins act as specialized receptors for highly specific autophagy (precision autophagy) of key components of the inflammasome and type I interferon response systems. TRIM20 targets the inflammasome...

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Source

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Identifiers

PMID: 26347139
DOI: 10.1083/jcb.201503023
PMCID: PMC4576868

Genes

TRIM21
NLRP1
NLRP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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