Article

<i>baal-nf</i> identifies motif-disrupting variants that decrease transcription factor binding affinity

2025-01-21

Abstract excerpt

Human traits vary in part due to genetically-determined change of transcription factor (TF) binding affinity within gene regulatory regions. However, few trait-causal variants or mechanisms are known. Here we propose 1,960 variants as strong candidates for causally altering human traits. They were discovered by baal-nf which uses ChIP-sequencing data to identify allelic imbalance at heterozygous sites (‘allele-sp...

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Literature Corpus work: 4bca4fea-cb99-55b5-b711-80707617dd06
DOI: 10.1101/2025.01.17.633399

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