Article

Functional dissection of complex and molecular trait variants at single nucleotide resolution

2024-05-06

Abstract excerpt

Identifying the causal variants and mechanisms that drive complex traits and diseases remains a core problem in human genetics. The majority of these variants have individually weak effects and lie in non-coding gene-regulatory elements where we lack a complete understanding of how single nucleotide alterations modulate transcriptional processes to affect human phenotypes. To address this, we measured the activity...

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Literature Corpus work: 2dac7202-4243-58c9-ad84-5bedb02f1dbb
DOI: 10.1101/2024.05.05.592437

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