Article

Aging-associated decline of phosphatidylcholine synthesis is a malleable trigger of natural mitochondrial aging

2024-04-28

Abstract excerpt

Mitochondrial dysfunction is a prominent hallmark of aging contributing to the functional decline of metabolic plasticity in late life. While genetic distortions of mitochondrial integrity elicit premature aging, the mechanisms leading to “natural” aging of mitochondria are less clear. Here we initially used proteomics, genetics and functional tests in wild type C. elegans and long-lived clk-1(qm30) and isp-1(q...

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Literature Corpus work: 4bc159c5-0f74-5fad-93e2-1c56f2550eb7
DOI: 10.1101/2024.04.25.591184

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