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An automated phenotype-based microscopy screen to identify pro-longevity interventions acting through mitochondria in C. elegans.

Biochimica et biophysica acta - 1 Nov 2015

Maglioni Silvia, Arsalan Nayna, Franchi Luigi, Hurd Alexander, Opipari Anthony W, Glick Gary D, Ventura Natascia

Abstract excerpt

Mitochondria are multifunctional organelles that play a central role in cellular homeostasis. Severe mitochondrial dysfunction leads to life-threatening diseases in humans and accelerates the aging process. Surprisingly, moderate reduction of mitochondrial function in different species has anti-aging effects. High-throughput screenings in the nematode Caenorhabditis elegans lead to the identification of several...

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PMID: 25979236
DOI: 10.1016/j.bbabio.2015.05.004

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