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Article

N-acetylcysteine and vitamin E rescue animal longevity and cellular oxidative stress in pre-clinical models of mitochondrial complex I disease.

Molecular genetics and metabolism - 1 Apr 2018

Polyak Erzsebet, Ostrovsky Julian, Peng Min, Dingley Stephen D, Tsukikawa Mai, Kwon Young Joon, McCormack Shana E, Bennett Michael, Xiao Rui, Seiler Christoph, Zhang Zhe, Falk Marni J

Abstract excerpt

Oxidative stress is a known contributing factor in mitochondrial respiratory chain (RC) disease pathogenesis. Yet, no efficient means exists to objectively evaluate the comparative therapeutic efficacy or toxicity of different antioxidant compounds empirically used in human RC disease. We postulated that pre-clinical comparative analysis of diverse antioxidant drugs having suggested utility in primary RC disease...

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Source

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Identifiers

PMID: 29526616
DOI: 10.1016/j.ymgme.2018.02.013
PMCID: PMC5891356

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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