Article
Erbb4 Deletion From Inhibitory Interneurons Causes Psychosis-Relevant Neuroimaging Phenotypes.
Schizophrenia bulletin - 3 May 2023
Kiemes Amanda, Serrano Navacerrada Maria Elisa, Kim Eugene, Randall Karen, Simmons Camilla, Rojo Gonzalez Loreto, Petrinovic Marija-Magdalena, Lythgoe David J, Rotaru Diana, Di Censo Davide, Hirschler Lydiane, Barbier Emmanuel L, Vernon Anthony C, Stone James M, Davies Cathy, Cash Diana, Modinos Gemma
Abstract excerpt
BACKGROUND AND HYPOTHESIS: Converging lines of evidence suggest that dysfunction of cortical GABAergic inhibitory interneurons is a core feature of psychosis. This dysfunction is thought to underlie neuroimaging abnormalities commonly found in patients with psychosis, particularly in the hippocampus. These include increases in resting cerebral blood flow (CBF) and glutamatergic metabolite levels, and decreases in...
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