Article

Modulating CRISPR-Cas genome editing using guide-complementary DNA oligonucleotides

2022-01-15

Abstract excerpt

CRISPR-Cas has revolutionized genome editing and has a great potential for applications, such as correcting human genetic disorders. To increase the safety of genome editing applications, CRISPR-Cas may benefit from strict control over Cas enzyme activity. Previously, anti-CRISPR proteins and designed oligonucleotides have been proposed to modulate CRISPR-Cas activity. Here we report on the potential of guide-comp...

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Literature Corpus work: 74f9a91d-8af6-5e72-9e30-86649188db1b
DOI: 10.1101/2022.01.15.475214

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