Article

Inosine misincorporation into mRNA triggers the integrated stress response and activates an innate immune gene expression signature

2026-01-17

Abstract excerpt

<h4>ABSTRACT</h4> The inosine triphosphate pyrophosphatase (ITPase) enzyme restricts levels of the non-canonical nucleotides (deoxy)inosine triphosphate (dITP/ITP) and prevents their aberrant misincorporation into nucleic acids. ITPase deficiency is associated with dilated cardiomyopathy and epileptic encephalopathy in humans and is usually fatal in infancy. It leads to pronounced inosine misincorporation into RN...

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Literature Corpus work: 4ba3986b-e9e5-5484-8c00-938c1ff83455
DOI: 10.64898/2026.01.16.699979

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