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Article

PUS10-induced tRNA fragmentation impacts retrotransposon-driven inflammation

20 May 2025

Abstract excerpt

Pseudouridine synthases (PUSs) catalyze the isomerization of uridine (U)-to-pseudouridine (Ψ) and have emerging roles in development and disease. How PUSs adapt gene expression under stress remains mostly unexplored. We identify an unconventional role for the Ψ "writer" PUS10 impacting intracellular innate immunity. Using Pus10 knockout mice, we uncover cell-intrinsic upregulation of interferon (IFN) signaling,...

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PMID: 40402745
DOI: 10.1016/j.celrep.2025.115735

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