Article

De novo purine synthesis reprograms the macrophage inflammatory response and the immune response in sepsis

2026-02-19

Abstract excerpt

<title>Abstract</title> <p> Sepsis is characterized by profound immunometabolic dysregulation, yet the role of purine precursor synthesis in immune reprogramming remains poorly defined. Intracellular purine nucleotides, such as ATP, are generated by <italic>de novo</italic> synthesis, which assembles purinosomes to build inosine monophosphate (IMP) from small precursors, or by the salvage pathway, which recycl...

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Literature Corpus work: 1be7bda0-07c6-5567-99a5-c49858cb6419
DOI: 10.21203/rs.3.rs-8887742/v1

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