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Article

Effects of glutamate and ivermectin on single glutamate-gated chloride channels of the parasitic nematode H. contortus.

PLoS pathogens - 1 Oct 2017

Atif Mohammed, Estrada-Mondragon Argel, Nguyen Bindi, Lynch Joseph W, Keramidas Angelo

Abstract excerpt

Ivermectin (IVM) is a widely-used anthelmintic that works by binding to and activating glutamate-gated chloride channel receptors (GluClRs) in nematodes. The resulting chloride flux inhibits the pharyngeal muscle cells and motor neurons of nematodes, causing death by paralysis or starvation. IVM resistance is an emerging problem in many pest species, necessitating the development of novel drugs. However, drug...

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Identifiers

PMID: 28968469
DOI: 10.1371/journal.ppat.1006663
PMCID: PMC5638611

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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