Article

Polymorphisms in Intron 1 of HLA-DRA Differentially Associate with Type 1 Diabetes and Celiac Disease and Implicate Involvement of Complement System Genes C4A and C4B

2023-06-20

Abstract excerpt

<h4>ABSTRACT</h4> Polymorphisms in genes in the human leukocyte antigen (HLA) class II region comprise the most important inherited risk factors for many autoimmune diseases including type 1 diabetes (T1D) and celiac disease (CD): both diseases are positively associated with the HLA-DR3 haplotype ( DRB1*03:01-DQA1*05:01-DQB1*02:01 ). Studies of two different populations have recently documented that T1D suscepti...

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Literature Corpus work: 4b872cfd-899a-543e-8e69-b9db456b53a1
DOI: 10.1101/2023.06.12.23291280

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