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Article

Polymorphisms in intron 1 of HLA-DRA differentially associate with type 1 diabetes and celiac disease and implicate involvement of complement system genes C4A and C4B.

eLife - 2 Feb 2026

Aydemir Ozkan, Bailey Jeffrey A, Agardh Daniel, Lernmark Åke, Noble Janelle A, Andersson Svärd Agnes, Blankenhorn Elizabeth P, Parikh Hemang M, Ziegler Anette-G, Toppari Jorma, Akolkar Beena, Hagopian William A, Rewers Marian J, Mordes John P

Abstract excerpt

Polymorphisms in genes in the human leukocyte antigen (HLA) class II region comprise the most important inherited risk factors for many autoimmune diseases, including type 1 diabetes (T1D) and celiac disease (CD): both diseases are positively associated with the HLA-DR3 haplotype (DRB1*03:01-DQA1*05:01-DQB1*02:01). Studies of two different populations have recently documented that T1D susceptibility in HLA-DR3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41627183
DOI: 10.7554/eLife.89068
PMCID: PMC12863718

Genes

C4A
C4B

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Polymorphisms in intron 1 of HLA-DRA differentially associate with type 1 diabetes and celiac disease and implicate involvement of complement system genes C4A and C4B.PMID 41627183Read ↗

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