Article
Mechanisms of genetic susceptibility to type I diabetes: beyond HLA.
Molecular genetics and metabolism - 1 Mar 2004
Anjos Suzana, Polychronakos Constantin
Abstract excerpt
An individual's predisposition to Type I diabetes (T1D) is largely determined by complex interactions between several genetic loci and other, nonheritable factors. In T1D, the HLA locus has been known for decades to contribute 50% of the inherited risk. Outside the HLA are many proposed candidate loci with smaller effects, but only two confirmed candidate genes, the INS-VNTR and the CTLA-4 genes, which together...
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