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Article

Tri-SNP polymorphism in the intron of HLA-DRA1 affects type 1 diabetes susceptibility in the Finnish population.

Human immunology - 1 Dec 2021

Nygård Lucas, Laine Antti-Pekka, Kiviniemi Minna, Toppari Jorma, Härkönen Taina, Knip Mikael, Veijola Riitta, Lempainen Johanna, Ilonen Jorma

Abstract excerpt

Genes in the HLA class II region include the most important inherited risk factors for type 1 diabetes (T1D) although also polymorphisms outside the HLA region modulate the predisposition to T1D. This study set out to confirm a recent observation in which a novel expression quantitative trait locus was formed by three single nucleotide polymorphisms (SNP) in the intron of HLA-DRA1 in DR3-DQ2 haplotypes. The SNPs...

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Identifiers

PMID: 34311991
DOI: 10.1016/j.humimm.2021.07.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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