Article

Ameliorating Ribosylation-induced Aβ Pathology by Berberine via Inhibiting mTOR/p70S6K Signaling

2020-07-07

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Berberine (BBR) plays a neuroprotective role in the pathogenesis of Alzheimer’s disease (AD), inhibiting β-amyloid (Aβ) production and promoting Aβ clearance. Advanced glycation end products (AGEs) promote Aβ aggregation and tau hyperphosphorylation. The activation of mTOR signaling occurring at the early stage of AD has a prominent impact on the Aβ production....

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Literature Corpus work: 4b765d71-1869-5268-82bd-70ee452eddb6
DOI: 10.21203/rs.3.rs-39378/v1

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