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Article

Dysfunction of the mTOR pathway is a risk factor for Alzheimer’s disease

8 May 2013

Abstract excerpt

BACKGROUND: The development of disease-modifying therapies for Alzheimer's disease is hampered by our lack of understanding of the early pathogenic mechanisms and the lack of early biomarkers and risk factors.We have documented the expression pattern of mTOR regulated genes in the frontal cortex of Alzheimer's disease patients. We have also examined the functional integrity of mTOR signaling in peripheral...

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PMID: 24252508
DOI: 10.1186/2051-5960-1-3

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