Article

Protein search processes mediated by chromatin topology

2023-12-13

Abstract excerpt

We investigate the role of compaction of chromatin domains in modulating search kinetics of proteins. Collapsed conformations of chromatin, characterised by long loops which bring distant regions of the genome into contact, and manifested structurally as Topologically Associated Domains (TADs) affect search kinetics of DNA associated transcription factors and other proteins. In this study, we investigate the role...

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Literature Corpus work: 4b6a2b74-fbb6-5bee-8bda-70ddbd925827
DOI: 10.1101/2023.12.12.571394

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