Article
Physical Principles of Retroviral Integration in the Human Genome
2018-01-12
Abstract excerpt
Certain retroviruses, including HIV, insert their DNA in a non-random fraction of the host genome via poorly understood selection mechanisms. Here, we develop a biophysical model for retroviral integrations as stochastic and quasi-equilibrium topological reconnections between polymers. We discover that physical effects, such as DNA accessibility and elasticity, play important and universal roles in this process. O...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 86026d6a-3caa-5eaa-889c-bfa1388ace30
- DOI
- 10.1101/247437