Article
A model-based prion vaccine protects a transgenic mouse line carrying a Gerstmann-Sträussler-Scheinker disease mutation.
Acta neuropathologica - 17 Apr 2026
Fang Andrew, Tang Xinli, Fleming Madeleine, Tancowny Brian, Wang Xiongyao, Wang YongLiang, Daude Nathalie, Dorosh Lyudmyla, Fleck Shelaine C, Rathod Vineet, Coustou Virginie, Cervantes Silvia A, Velásquez Camilo Duque, Westaway David, Aiken Judd, McKenzie Debbie, Telling Glenn, Stepanova Maria, Saupe Sven J, Siemer Ansgar B, Wille Holger
Abstract excerpt
Prion diseases are transmissible, fatal, neurodegenerative disorders driven by the conformational misfolding of the cellular prion protein (PrPC) into an infectious, aggregation-prone conformer (PrPSc). While the accumulation of PrPSc represents the central pathogenic event, targeting it directly and specifically has proven difficult due to its structural heterogeneity and similarity to PrPC. Consequently,...
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