Article

A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity

2018-08-10

Abstract excerpt

Antibodies to the prion protein, PrP, represent a promising therapeutic approach against prion diseases but the neurotoxicity of certain anti-PrP antibodies has caused concern. Here we describe scPOM-bi, a bispecific antibody designed to function as a molecular prion tweezer. scPOM-bi combines the complementarity-determining regions of the neurotoxic antibody POM1 and the neuroprotective POM2, which bind the globu...

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Identifiers and source

Literature Corpus work: 31465bde-8130-5406-84e7-17ce67fc47f1
DOI: 10.1101/386763

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