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Challenges and Prospects of Patient-Derived Xenografts for Cancer Research

31 Aug 2023

Abstract excerpt

We discuss the importance of the in vivo models in elucidating cancer biology, focusing on the patient-derived xenograft (PDX) models, which are classic and standard functional in vivo platforms for preclinical evaluation. We provide an overview of the most representative models, including cell-derived xenografts (CDX), tumor and metastatic cell-derived xenografts, and PDX models utilizing humanized mice (HM)....

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PMID: 37686627
DOI: 10.3390/cancers15174352

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