Generation of Orthotopic Patient-Derived Xenograft in Humanized Mice for Evaluation of Emerging Targeted Therapies and Immunotherapy Combinations for Melanoma

Abstract excerpt

Current methodologies for developing patient-derived xenografts (PDX) in humanized mice in preclinical trials to test response to immune-based therapies are limited by graft versus host disease. Here we compared two approaches for establishing PDX tumors in humanized mice: 1) PDX are first established in immune-deficient mice; 2) PDX are initially established in humanized mice, before transplanting established PDX...

Topics

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• CAR-T cell therapy research
• Disease Models, Animal
• Melanoma
• Mitogen-Activated Protein Kinase Kinases
• Mutation
• Ocular Oncology and Treatments
• Protein Kinase Inhibitors
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

87f96307-e21c-5402-a9dc-f161c27bf390

DOI

10.20944/preprints202307.0566.v1