Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide analyses identify KLF4 as an important negative regulator in T-cell acute lymphoblastic leukemia through directly inhibiting T-cell associated genes

1 Jan 2015

Abstract excerpt

BACKGROUND: Kruppel-like factor 4 (KLF4) induces tumorigenesis or suppresses tumor growth in a tissue-dependent manner. However, the roles of KLF4 in hematological malignancies and the mechanisms of action are not fully understood. METHODS: Inducible KLF4-overexpression Jurkat cell line combined with mouse models bearing cell-derived xenografts and primary T-cell acute lymphoblastic leukemia (T-ALL) cells from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Myeloid Leukemia Treatments
Share to Genetic Syndromes and Imprinting
Share to Kruppel-like factors research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25644173
DOI: 10.1186/s12943-014-0285-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide analyses identify KLF4 as an important negative regulator in T-cell acute lymphoblastic leukemia through directly inhibiting T-cell associated genesPMID 25644173Read ↗

Inhibition of BCL11B induces downregulation of PTK7 and results in growth retardation and apoptosis in T-cell acute lymphoblastic leukemiaSemantic proximity Read ↗

miR-2909-mediated regulation of KLF4: a novel molecular mechanism for differentiating between B-cell and T-cell pediatric acute lymphoblastic leukemiasSemantic proximity Read ↗

Gene expression profiling, prognosis, and immune microenvironment of KLF4 in malignanciesSemantic proximity Read ↗

Super Enhancer Regulatory Gene FYB1 Promotes the Progression of T Cell Acute Lymphoblastic Leukemia by Activating IGLL1Semantic proximity Read ↗

Somatic FOXC1 insertion mutation remodels the immune microenvironment and promotes the progression of childhood acute lymphoblastic leukemia.Semantic proximity Read ↗

KLF4 suppresses transformation of pre-B cells by ABL oncogenesSemantic proximity Read ↗

JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemiaSemantic proximity Read ↗

Alternative Splicing of Tcfl5 Fine-tunes Notch1 Transcriptional Output and Cell Fate Decisions in T-cell Acute Lymphoblastic LeukemiasSemantic proximity Read ↗

Regulatory Network and Prognostic Effect Investigation of PIP4K2A in Leukemia and Solid CancersSemantic proximity Read ↗

Egr2-independent, Klf1-mediated induction of PD-L1 in CD4+ T cellsSemantic proximity Read ↗

Inducible transgene expression in PDX models <i>in vivo</i> identifies KLF4 as therapeutic target for B-ALLSemantic proximity Read ↗

MYC in T-cell acute lymphoblastic leukemia: functional implications and targeted strategiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.