Article

A platform of robust patient-derived leukemia models covering subgroups for which no cell lines exist

2025-09-28

Abstract excerpt

Preclinical cancer research requires robust model systems, especially for poor prognosis entities like acute myeloid leukemia (AML), a highly aggressive blood cancer. Here, primary tumor cells from 137 AML patients of all age groups were transplanted into immune compromised mice to generate patient-derived xenografts (PDX). From these, 23 models enable robust, virtually endless serial re-transplantation and are am...

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Literature Corpus work: a7fd3e27-4543-5e94-8f7a-d4c47c39ba7a
DOI: 10.1101/2025.09.26.677299

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