Article

<i>In vivo</i> inducible reverse genetics in patients’ tumors to identify individual therapeutic targets

2020-05-03

Abstract excerpt

High-throughput sequencing describes multiple alterations in each tumor (1), but their functional relevance is often unclear. Clinic-close, individualized molecular model systems are required for functional validation and to identify therapeutic targets of high significance for each patient (2). Here, we established a Cre-ER T 2 -loxP based inducible RNAi-mediated gene silencing system in patient-derived xenogra...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 89340b04-76b3-5654-a70f-f2c1e09ba98d
DOI: 10.1101/2020.05.02.073577

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>In vivo</i> inducible reverse genetics in patients’ tumors to identify individual therapeutic targetsDOI 10.1101/2020.05.02.073577Read

A platform of robust patient-derived leukemia models covering subgroups for which no cell lines existSemantic proximity Read

Inducible transgene expression in PDX models <i>in vivo</i> identifies KLF4 as therapeutic target for B-ALLSemantic proximity Read

An advanced preclinical mouse model for acute myeloid leukemia using patients' cells of various genetic subgroups and in vivo bioluminescence imaging.Semantic proximity Read

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.Semantic proximity Read

Functional precision oncology for follicular lymphoma with patient-derived xenograft in avian embryosSemantic proximity Read

Mouse models of human AML accurately predict chemotherapy response.Semantic proximity Read

Discovery of tumoricidal DNA oligonucleotides by effect-directed <i>in-vitro</i> evolutionSemantic proximity Read

Using a lentiviral Tet-regulated miR-E shRNA dual color vector to evaluate gene function in human leukemic stem cells in vivoSemantic proximity Read

Sequential gene targeting to make chimeric tumor models with de novo chromosomal abnormalities.Semantic proximity Read

Rexin-G, a targeted genetic medicine for cancer.Semantic proximity Read

Direct genome editing of patient-derived xenografts using CRISPR-Cas9 enables rapid <i>in vivo</i> functional genomicsSemantic proximity Read

Efficacy of Minnelide in a Next-Generation Dual-Recombinase Regulated Genetically Engineered Mouse Model of CIC::DUX4 SarcomaSemantic proximity Read