Article

Modeling <i>IKZF1</i> lesions in B-ALL reveals distinct chemosensitivity patterns and potential therapeutic vulnerabilities

2020-05-27

Abstract excerpt

IKAROS family zinc finger 1 ( IKZF1 ) alterations represent a diverse group of genetic lesions that are associated with an increased risk of relapse in B-lymphoblastic leukemia (B-ALL). Due to the heterogeneity of concomitant lesions it remains unclear how IKZF1 abnormalities directly affect cell function and therapy resistance and whether their consideration as a prognostic indicator is valuable in improving ou...

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Literature Corpus work: 8961cc7b-39fa-541d-8d7e-8263b8ce3ab1
DOI: 10.1101/2020.05.26.109579

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