Article

PDX models of relapsed pediatric AML preserve global gene expression patterns and reveal therapeutic targets

2022-02-01

Abstract excerpt

As patient-derived xenograft (PDX) models of acute myeloid leukemia (AML) become increasingly common tools for preclinical evaluation of targeted therapies it becomes important to consider the fidelity with which this system recapitulates the disease state found in patients. Gene expression profiling of patient blasts has been successfully used to identify distinct subtypes of AML to uncover sub-type specific vuln...

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Literature Corpus work: 05a7153f-e039-5af3-95bf-6e717fc34c82
DOI: 10.1101/2022.01.31.478534

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